Compare Treatments · Depth, Pain & Genuine Machine Check
Rejuran Healer vs. Profhilo
0.5–1.5mm salmon PN dermal repair vs. 2.5–3.5mm BAP hybrid-HA bio-remodelling. Both lit on one cross-section — A solid, B dashed — with every layer either reaches outlined.
Depth chartSkin Depth Chart (Tap to Zoom) ↓ Download WebP
Side-by-Side Treatment Comparison
1 · How It Works & Maker
Intradermal PN (Polynucleotide 2%)
PharmaResearch (Korea)
Intradermal PN / BAP Hybrid HA
IBSA Derma (Switzerland)
2 · Skin Layers & Exact Depth
0.5–1.5mm
- Papillary Dermis (0.3–1.5mm)
2.5–3.5mm
- Reticular Dermis (1.5–3.0mm)
- Subcutaneous Fat (3.0–4.2mm)
3 · Pain Level & Numbing
7/10
Topical numbing 30–45 minutes; injector gun reduces discomfort.
3/10
Usually none — only 10 injection points.
4 · Recovery Time & Repeat Schedule
3–5 days micro-bumps / subdermal papules (gun) · 1–2 days (manual)
Repeat: Every 3–4 weeks × 3, then maintenance every 6 months
24–48 hrs small injection bumps
Repeat: 2 sessions 4 weeks apart, then every 6 months
5 · Singapore 2026 Fair Price (incl. GST)
S$480–S$780
Typical median: S$650 · Per 2ml pre-filled syringe (manual serial puncture or injector gun)
Check My Quote →S$780–S$1,150
Typical median: S$950 · Per 2ml syringe (5-point BAP technique per side)
Check My Quote →6 · How to Spot a Fake / Clone Machine
Request the sealed 2ml syringe box and confirm the lot number and expiry. The full 2ml should be injected undiluted — ask directly whether saline or HA is mixed in.
- ✓Sealed PharmaResearch box with lot & expiry
- ✓Syringe opened in front of you
- ✓Full 2ml, undiluted
Each authentic box carries a scannable QR / lot code from the authorised Singapore distributor (NeoAsia). Ask the doctor to scan it with you before opening.
- ✓Box QR code scanned in front of you
- ✓IBSA lot number and expiry match
- ✓Syringe unopened until the procedure starts
Goes deeper: Profhilo (Subcutaneous Fat)
Less painful: Profhilo (3/10 vs 7/10)
Lower median per session: Rejuran Healer (S$650 vs S$950)
Rejuran Healer · Rejuran S · Rejuran i
Rejuran Healer
Salmon-DNA polynucleotides deposited as intradermal blebs stimulate fibroblast repair and dermal regeneration.
IndicationsThin skin, fine lines, enlarged pores, post-acne texture, barrier repair
Audit a Rejuran Healer quote · SG median S$650 →- Energy / Modality
- Intradermal PN (Polynucleotide 2%)
- Target Anatomical Layer
- Papillary Dermis 0.3–1.5mm
- Clinical Pain Index
- 7/10
- Topical numbing 30–45 minutes; injector gun reduces discomfort.
- Social Downtime
- 3–5 days micro-bumps / subdermal papules (gun) · 1–2 days (manual)
- Evidence-Based Interval
- Every 3–4 weeks × 3, then maintenance every 6 months
Counterfeit / Clone Machine Warning
Request the sealed 2ml syringe box and confirm the lot number and expiry. The full 2ml should be injected undiluted — ask directly whether saline or HA is mixed in.
- ✓Sealed PharmaResearch box with lot & expiry
- ✓Syringe opened in front of you
- ✓Full 2ml, undiluted
- Halley Medical Aesthetics
Orchard Road · Tier A
Comparison Matrix
| Device | Energy / Modality | Target Layer | Pain | Downtime | Interval | SG Median |
|---|---|---|---|---|---|---|
| Pico Laser Quanta · Candela · Cynosure · Fotona |
1064nm/532nm Picosecond Nd:YAG | Epidermis 0.1–0.3mm (532nm) · Papillary Dermis 0.3–1.5mm (1064nm / MLA) | 2/10 | 0 hrs (toning) · 24–48 hrs erythema (fractional) | Every 2–4 weeks × 5–10 (toning) · every 4 weeks × 3–4 (fractional) | S$350 |
| Sylfirm X Viol Co., Ltd. (Korea) |
300μm–4.0mm Bipolar Pulsed/CW RF | Basement Membrane 0.3mm (PW) · Papillary & Reticular Dermis to 3.0mm+ (CW) | 5/10 | 24–48 hrs erythema · pinpoint marks 2–3 days | Every 4 weeks × 3–5 | S$680 |
| Thermage FLX Solta Medical (Bausch Health) |
6.78 MHz Monopolar RF | Reticular Dermis 1.5–3.0mm · Fibrous Septae to ~4.0mm | 6/10 | 0–24 hrs mild erythema | Annual single session (12–18 months) | S$3,500 |
| Ultherapy PRIME Merz Aesthetics |
MHz Micro-Focused Ultrasound + Real-Time Ultrasound Imaging | 1.5mm Dermis · 3.0mm Deep Dermis · 4.5mm SMAS Fibromuscular Layer | 8/10 | 0 hrs social downtime · tenderness 1–2 weeks | Annual single session (12–18 months) | S$3,200 |
| Sofwave Sofwave Medical |
SUPERB Synchronous Ultrasound Parallel Beam | Mid-Dermis Parallel Cylinder Zone 1.5mm (spares SMAS & subcutaneous fat) | 6/10 | 0–24 hrs mild redness | Annual single session (optional 6-month top-up) | S$3,200 |
| Potenza Cynosure |
4-Mode Monopolar/Bipolar RF Microneedling | 0.5mm–4.0mm Dual-Depth (Tiger Tip treats two dermal depths per pass) | 6/10 | 24–72 hrs erythema · pinpoint marks | Every 4–6 weeks × 3 | S$850 |
| Fotona 4D Fotona |
2940nm Er:YAG + 1064nm Nd:YAG (4 modes) | 0.1mm Epidermal Peel · 1.0–3.0mm Bulk Dermal Heating · Intraoral Mucosal Vector | 4/10 | 0–24 hrs (SupErficial: 2–3 days fine peeling) | Every 4–6 weeks × 3, then every 6 months | S$750 |
| Rejuran Healer PharmaResearch (Korea) |
Intradermal PN (Polynucleotide 2%) | Papillary Dermis 0.5–1.5mm (intradermal blebs) | 7/10 | 3–5 days micro-bumps / subdermal papules (gun) · 1–2 days (manual) | Every 3–4 weeks × 3, then maintenance every 6 months | S$650 |
| Profhilo IBSA Derma (Switzerland) |
Intradermal PN / BAP Hybrid HA | Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots) | 3/10 | 24–48 hrs small injection bumps | 2 sessions 4 weeks apart, then every 6 months | S$950 |
| Botulinum Toxin Merz · AbbVie (Allergan) · Ipsen / Galderma |
Botulinum Toxin Type A Neuromodulator | Intramuscular (Masseter / Frontalis / Corrugator >4.5mm) · Intradermal Micro-Botox (0.8–1.2mm) | 3/10 | 0 hrs · pinpoint bumps for 15–30 minutes | Every 3–4 months (masseter 4–6 months) | S$650 |
| Juvelook / Lenisna Vaim Co. (Korea) |
PDLLA + Non-Crosslinked HA Biostimulator | Papillary to Reticular Dermis 1.0–1.8mm (Juvelook 50mg) · Subdermal 2.5–4.0mm (Lenisna 200mg) | 5/10 | 1–3 days micro-papules | Every 4–6 weeks × 2–3, then yearly | S$780 |
| Skinvive / Belotero Revive AbbVie (Allergan) · Merz |
Microdroplet Intradermal HA (+ Glycerol) | Superficial Intradermal Microdroplet Depot 0.8–1.2mm | 4/10 | 24–48 hrs small bumps / redness | Every 6 months | S$980 |
Pillar II · Singapore 2026 Fair Price
Audit Both Quotes
Protocol A · Per 2ml pre-filled syringe (manual serial puncture or injector gun)
Rejuran Healer
Fair S$480–S$780 · median S$650
Rejuran under ~S$380 per syringe can indicate dilution or a split syringe shared across patients.
Audit Your Rejuran Quote →Protocol B · Per 2ml syringe (5-point BAP technique per side)
Profhilo
Fair S$780–S$1,150 · median S$950
Profhilo under ~S$650 per syringe warrants checking the box QR code and lot number in front of you.
Audit Your Profhilo Quote →SGD incl. 9% GST · medians are per each treatment's own reference dose, so compare them as typical courses, not like-for-like units · editorial benchmarks, not clinic tariffs.
Clinic Dossier · Singapore
Matched Singapore Clinics
Rejuran Healer
- Halley Medical Aesthetics
Orchard Road · Tier A
Profhilo
- Halley Medical Aesthetics
Orchard Road · Tier A
- Bio Aesthetic Laser Clinic (Palais Renaissance)
Orchard Road · Tier B
Clinic Dossier · Compare
Compare Clinics With Rejuran Healer or Profhilo
Clinics in the dossier that advertise Rejuran Healer or Profhilo. Advertised is not inspected: ask to see the brand, lot and expiry on the product.
-
Bio Aesthetic Laser Clinic (Palais Renaissance)
Singapore · Medical Aesthetic Clinic
Orchard Exit 11 · 292 mTier BLists: Profhilo / Skin Boosters
-
Lienjang Clinic (Gangnam Flagship)
Seoul · Medical Aesthetic Clinic
Gangnam-gu, SeoulTier BLists: Rejuran Healer PN
Section V · Before Rejuran Healer or Profhilo
Pre-Procedure Washout & Post-Procedure Barrier Support
Injectables usually need no washout beforehand, but keep exfoliating acids, retinoids and spicule products off the injected area for 24–48 hours after.
Compare audited examples: retinoid, exfoliating acid, spicule →After the session · Recovery & photoprotection
- Cicaplast Baume B5+ Soothing Therapeutic CreamLa Roche-Posay · Barrier / Peptide / Hydrator
- Atobarrier 365 CreamAestura · Barrier / Peptide / Hydrator
- Madagascar Centella Hyalu-Cica Water-Fit Sun Serum SPF50+ PA++++SKIN1004 · Photoprotection
Editorial guidance from common clinic practice, not medical advice: your treating doctor's pre- and post-care instructions come first.
How It Works
RF Microneedling & Intradermal Boosters
Field Notes
Frequently Asked Questions
What is the difference in skin depth and mechanism between Rejuran Healer and Profhilo?
Rejuran Healer (Intradermal PN (Polynucleotide 2%)) works at Papillary Dermis 0.5–1.5mm (intradermal blebs) — Papillary Dermis (0.3–1.5mm). Salmon-DNA polynucleotides deposited as intradermal blebs stimulate fibroblast repair and dermal regeneration. Profhilo (Intradermal PN / BAP Hybrid HA) works at Deep Dermis / Superficial Subcutaneous ~2.5–3.5mm (BAP depots) — Reticular Dermis (1.5–3.0mm), Subcutaneous Fat (3.0–4.2mm). Thermally stabilised hybrid cooperative HA complex (32mg H-HA + 32mg L-HA) diffuses from 5 Bio Aesthetic Points per side for bio-remodelling. Profhilo reaches the deeper layer (Subcutaneous Fat).
Which is more painful or has longer downtime: Rejuran Healer or Profhilo?
Rejuran Healer: pain 7/10 — Topical numbing 30–45 minutes; injector gun reduces discomfort. Downtime 3–5 days micro-bumps / subdermal papules (gun) · 1–2 days (manual); interval Every 3–4 weeks × 3, then maintenance every 6 months. Profhilo: pain 3/10 — Usually none — only 10 injection points. Downtime 24–48 hrs small injection bumps; interval 2 sessions 4 weeks apart, then every 6 months. Profhilo is the gentler of the two on Beauty.net's clinical pain index.
How much does Rejuran Healer vs. Profhilo cost in Singapore in 2026 and which should I choose?
Beauty.net's 2026 Singapore benchmarks (SGD incl. 9% GST, editorial percentiles rather than clinic tariffs): Rejuran Healer S$480–S$780, median S$650 (Per 2ml pre-filled syringe (manual serial puncture or injector gun)); Profhilo S$780–S$1,150, median S$950 (Per 2ml syringe (5-point BAP technique per side)). Choose by indication rather than price — Rejuran Healer: Thin skin, fine lines, enlarged pores, post-acne texture, barrier repair; Profhilo: Skin laxity, crepiness, hydration, neck and décolletage. A doctor's assessment of your skin decides which layer needs treating.